Sunitinib Rechallange in Metastatic Renal Cell Carcinoma Patients
نویسندگان
چکیده
منابع مشابه
Sunitinib in patients with metastatic renal cell carcinoma.
CONTEXT Current treatment options for metastatic renal cell carcinoma (RCC) are limited and there is a need to identify novel and effective therapies. Sunitinib malate is an oral multitargeted tyrosine kinase inhibitor, which has shown activity in an initial study of cytokine-refractory metastatic RCC patients. OBJECTIVE To confirm the antitumor efficacy of sunitinib as second-line treatment ...
متن کاملSunitinib in patients with metastatic renal cell carcinoma: Birmingham experience.
Sunitinib is a novel, multi-targeted receptor tyrosine kinase inhibitor, which has demonstrated evidence of improved survival when compared to interferon (IFN)-alpha in patients with metastatic renal cell carcinoma (RCC). Recently published National Institute for Health and Clinical Excellence guidance recommends sunitinib as a first-line treatment option for patients with advanced and/or metas...
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Sunitinib malate is an oral multitargeted tyrosine kinase inhibitor exhibiting antiangiogenic activity. Sunitinib demonstrated improved outcomes in comparison to interferon-α in a large phase III study of treatment naïve patients with metastatic renal cell carcinoma. Maintaining patients on sunitinib treatment is essential for a sustained disease control as higher exposure to sunitinib has been...
متن کاملModified Schedule Sunitinib in Metastatic Renal Cell Carcinoma
Background: New targeted therapies have revolutionized the treatment landscape of metastatic renal cell carcinoma over the last decade. Sunitinib has demonstrated high activity in renal cell carcinoma (RCC), still complete remission is not a common occurrence in patients. In patient achieving complete response, continuation of therapy beyond complete response is debatable. Cytoreductive nephrec...
متن کاملPazopanib versus sunitinib in metastatic renal-cell carcinoma.
BACKGROUND Pazopanib and sunitinib provided a progression-free survival benefit, as compared with placebo or interferon, in previous phase 3 studies involving patients with metastatic renal-cell carcinoma. This phase 3, randomized trial compared the efficacy and safety of pazopanib and sunitinib as first-line therapy. METHODS We randomly assigned 1110 patients with clear-cell, metastatic rena...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2012
ISSN: 0923-7534
DOI: 10.1016/s0923-7534(20)33421-9